To remove just python-mako package itself from Debian Unstable (Sid) execute on terminal:
sudo apt-get remove python-mako
Uninstall python-mako and it's dependent packages
To remove the python-mako package and any other dependant package which are no longer needed from Debian Sid.
sudo apt-get remove --auto-remove python-mako
If you also want to delete configuration and/or data files of python-mako from Debian Sid then this will work:
sudo apt-get purge python-mako
To delete configuration and/or data files of python-mako and it's dependencies from Debian Sid then execute:
sudo apt-get purge --auto-remove python-mako
More information about apt-get remove
Advanced Package Tool, or APT, is a free software user interface that works with core libraries to handle the installation and removal of software on Debian, Ubuntu and other Linux distributions. APT simplifies the process of managing software on Unix-like computer systems by automating the retrieval, configuration and installation of software packages, either from precompiled files or by compiling source code.
apt-get is the command-line tool for handling packages, and may be considered the user's "back-end" to other tools using the APT library.
apt-get remove is identical to install except that packages are removed instead of installed. Note that removing a package leaves its configuration files on the system. If a plus sign is appended to the package name (with no intervening space), the identified package will be installed instead of removed.